RESEARCH

AHCC Supplement Clinical Trials

  • AHCC® Supplementation to Support Immune Function to Clear Persistent Human Papillomavirus Infections. Smith JA, Gaikwad AA, Mathew L, Rech B, Faro JP, Lucci JA 3rd, Bai Y, Olsen RJ, Byrd TT. (PubMed)
  • AHCC®, a Standardized Extract of Cultured Lentinula Edodes Mycelia, Promotes the Anti-Tumor Effect of Dual Immune Checkpoint Blockade Effect in Murine Colon Cancer. Park HJ, Boo S, Park I, Shin MS, Takahashi T, Takanari J, Homma K, Kang I. (PubMed) 
  • The Effects of AHCC®, a Standardized Extract of Cultured Lentinura edodes Mycelia, on Natural Killer and T Cells in Health and Disease: Reviews on Human and Animal Studies. Shin MS, Park HJ, Maeda T, Nishioka H, Fujii H, Kang I. (PubMed)
  • From Bench to Bedside: Evaluation of AHCC Supplementation to Modulate the Host Immunity to Clear High-Risk Human Papillomavirus Infections. Smith JA, Mathew L, Gaikwad A, Rech B, Burney MN, Faro JP, Lucci JA 3rd, Bai Y, Olsen RJ, Byrd TT. (PubMed) 
  • Effects of AHCC® on Immune and Stress Responses in Healthy Individuals. Takanari J, Sato A, Waki H, Miyazaki S, Uebaba K, Hisajima T. (PubMed) 
  • Potential Role for Active Hexose Correlated Compound (AHCC) in Treatment of Recurrent Respiratory Papillomatosis. Gau VL, Benninger MS. (PubMed) 
  • Could Active Hexose Correlated Compound (AHCC) Currently Be an Appropriate Choice to Clear Human Papillomavirus Infection? Farasatinasab M, Nassiri S. (PubMed) 
  • Active Hexose Correlated Compound (AHCC) Inhibits the Proliferation of Ovarian Cancer Cells by Suppressing Signal Transducer and Activator of Transcription 3 (STAT3) Activation. Choi JY, Lee S, Yun SM, Suh DH, Kim K, No JH, Jeong EH, Kim YB. (PubMed) 
  • AHCC Activation and Selection of Human Lymphocytes via Genotypic and Phenotypic Changes to an Adherent Cell Type: A Possible Novel Mechanism of T Cell Activation. Olamigoke L, Mansoor E, Mann V, Ellis I, Okoro E, Wakame K, Fuji H, Kulkarni A, Francoise Doursout M, Sundaresan A. (PubMed) 
  • Effect of Active Hexose Correlated Compound (AHCC) in alcohol-induced liver enzyme elevation. Kim H, Kim JH, Im JA. (PubMed) 
  • An evidence-based systematic review of active hexose correlated compound (AHCC) by the Natural Standard Research Collaboration. Ulbricht C, Brigham A, Bryan JK, Catapang M, Chowdary D, Costa D, Culwell S, D’Auria D, Giese N, Iovin R, Isaac R, Juturu V, Liu A, Mintzer M, Rusie E, Shaffer M, Windsor RC. (PubMed) 
  • Active Hexose Correlated Compound (AHCC) promotes an intestinal immune response in BALB/c mice and in primary intestinal epithelial cell culture involving toll-like receptors TLR-2 and TLR-4. Mallet JF, Graham É, Ritz BW, Homma K, Matar C. (PubMed) 
  • Evaluation of Active Hexose Correlated Compound (AHCC) in Combination With Anticancer Hormones in Orthotopic Breast Cancer Models. Mathew L, Gaikwad A, Gonzalez A, Nugent EK, Smith JA. (PubMed) 
  • Therapeutic effect of Active Hexose-Correlated Compound (AHCC) combined with CpG-ODN (oligodeoxynucleotide) in B16 melanoma murine model. Ignacio RM, Kim CS, Kim YD, Lee HM, Qi XF, Kim SK. (PubMed) 
  • Genotoxicity and subchronic toxicity evaluation of Active Hexose Correlated Compound (AHCC). Fujii H, Nishioka N, Simon RR, Kaur R, Lynch B, Roberts A. (PubMed) 
  • Activation of NF-E2 p45-related factor-2 transcription and inhibition of intestinal tumor development by AHCC, a standardized extract of cultured Lentinula edodes mycelia. Takahashi M, Fujii G, Hamoya T, Kurokawa Y, Matsuzawa Y, Miki K, Komiya M, Narita T, Mutoh M. (PubMed) 
  • Modulation of T Regulatory and Dendritic Cell Phenotypes Following Ingestion of Bifidobacterium longum, AHCC® and Azithromycin in Healthy Individuals. Chowdhury AH, Cámara M, Verma C, Eremin O, Kulkarni AD, Lobo DN. (PubMed) 
  • Alleviating Effect of Active Hexose Correlated Compound (AHCC) on Chemotherapy-Related Adverse Events in Patients with Unresectable Pancreatic Ductal Adenocarcinoma. Yanagimoto H, Satoi S, Yamamoto T, Hirooka S, Yamaki S, Kotsuka M, Ryota H, Michiura T, Inoue K, Matsui Y, Tsuta K, Kon M. (PubMed) 
  • The nutritional supplement Active Hexose Correlated Compound (AHCC) has direct immunomodulatory actions on intestinal epithelial cells and macrophages involving TLR/MyD88 and NF-κB/MAPK activation. Daddaoua A, Martínez-Plata E, Ortega-González M, Ocón B, Aranda CJ, Zarzuelo A, Suárez MD, de Medina FS, Martínez-Augustin O. (PubMed) 
  • The Effects of Active Hexose Correlated Compound (AHCC) on Levels of CD4+ and CD8+ in Patients with Epithelial Ovarian Cancer or Peritoneal Cancer Receiving Platinum Based Chemotherapy. Suknikhom W, Lertkhachonsuk R, Manchana T. (PubMed) 
  • Immunological effect of active hexose correlated compound (AHCC) in healthy volunteers: a double-blind, placebo-controlled trial. Terakawa N, Matsui Y, Satoi S, Yanagimoto H, Takahashi K, Yamamoto T, Yamao J, Takai S, Kwon AH, Kamiyama Y. (PubMed) 
  • MicroRNA signature in the chemoprevention of functionally-enriched stem and progenitor pools (FESPP) by Active Hexose Correlated Compound (AHCC). Graham ÉA, Mallet JF, Jambi M, Nishioka H, Homma K, Matar C. (PubMed) 
  • Increased Efficacy of Oral Fixed-Dose Combination of Amphotericin B and AHCC® Natural Adjuvant against Aspergillosis. Pérez-Cantero A, Serrano DR, Navarro-Rodríguez P, Schätzlein AG, Uchegbu IF, Torrado JJ, Capilla J. (PubMed) 
  • Prognostic improvement of patients with advanced liver cancer after active hexose correlated compound (AHCC) treatment. Cowawintaweewat S, Manoromana S, Sriplung H, Khuhaprema T, Tongtawe P, Tapchaisri P, Chaicumpa W. (PubMed) 
  • A Phase I study of the safety of the nutritional supplement, active hexose correlated compound, AHCC, in healthy volunteers. Spierings EL, Fujii H, Sun B, Walshe T. (PubMed) 
  • Disruption of endothelial adherens junction by invasive breast cancer cells is mediated by reactive oxygen species and is attenuated by AHCC. Haidari M, Zhang W, Wakame K. (PubMed) 
  • Possible therapeutic role of a highly standardized mixture of active compounds derived from cultured Lentinula edodes mycelia (AHCC) in patients infected with 2019 novel coronavirus. Di Pierro F, Bertuccioli A, Cavecchia I. (PubMed) 
  • Reduction of adverse effects by a mushroom product, active hexose correlated compound (AHCC) in patients with advanced cancer during chemotherapy–the significance of the levels of HHV-6 DNA in saliva as a surrogate biomarker during chemotherapy. Ito T, Urushima H, Sakaue M, Yukawa S, Honda H, Hirai K, Igura T, Hayashi N, Maeda K, Kitagawa T, Kondo K. (PubMed) 
  • A standardized extract of cultured Lentinula edodes mycelia downregulates cortactin in gemcitabine-resistant pancreatic cancer cells. Islam S, Kitagawa T, Baron B, Kuhara K, Nagayasu H, Kobayashi M, Chiba I, Kuramitsu Y. (PubMed) 
  • A Standardized Extract of Lentinula edodes Cultured Mycelium Inhibits Pseudomonas aeruginosa Infectivity Mechanisms. Tena-Garitaonaindia M, Ceacero-Heras D, Montoro MDMM, de Medina FS, Martínez-Augustin O, Daddaoua A. (PubMed) 
  • Preventing Recurrence of Hepatocellular Carcinoma After Curative Hepatectomy With Active Hexose-correlated Compound Derived From Lentinula edodes Mycelia. Kamiyama T, Orimo T, Wakayama K, Kakisaka T, Shimada S, Nagatsu A, Asahi Y, Aiyama T, Kamachi H, Taketomi A. (PubMed) 
  • Active hexose-correlated compound enhances extrinsic-pathway-mediated apoptosis of Acute Myeloid Leukemic cells. Fatehchand K, Santhanam R, Shen B, Erickson EL, Gautam S, Elavazhagan S, Mo X, Belay T, Tridandapani S, Butchar JP. (PubMed) 
  • Nutritional impact of active hexose-correlated compound for patients with resectable or borderline-resectable pancreatic cancer treated with neoadjuvant therapy. Hashimoto D, Satoi S, Yamamoto T, Yamaki S, Ishida M, Ryota H, Sakaguchi T, Hirooka S, Inoue K, Sekimoto M. (PubMed) 
  • Active hexose correlated compound exerts therapeutic effects in lymphocyte driven colitis. Mascaraque C, Suárez MD, Zarzuelo A, Sánchez de Medina F, Martínez-Augustin O. (PubMed) 
  • Efficacy of active hexose correlated compound on survival of patients with resectable/borderline resectable pancreatic cancer: a study protocol for a double-blind randomized phase II study. Hashimoto D, Satoi S, Ishikawa H, Kodera Y, Kamei K, Hirano S, Fujii T, Uemura K, Tsuchida A, Yamada S, Yamamoto T, Hirota K, Sekimoto M. (PubMed) 
  • Active hexose-correlated compound down-regulates sex-determining region Y-box 2 of pancreatic cancer cells. Nawata J, Kuramitsu Y, Wang Y, Kitagawa T, Tokuda K, Baron B, Akada J, Suenaga S, Kaino S, Maehara S, Maehara Y, Sakaida I, Nakamura K. (PubMed) 
  • Short-term supplementation with active hexose correlated compound improves the antibody response to influenza B vaccine. Roman BE, Beli E, Duriancik DM, Gardner EM. (PubMed) 
  • Adenosine, a hepato-protective component in active hexose correlated compound: its identification and iNOS suppression mechanism. Tanaka Y, Ohashi S, Ohtsuki A, Kiyono T, Park EY, Nakamura Y, Sato K, Oishi M, Miki H, Tokuhara K, Matsui K, Kaibori M, Nishizawa M, Okumura T, Kwon AH. (PubMed) 
  • CUB Domain-containing Protein 1 (CDCP1) Is Down-regulated by Active Hexose-correlated Compound in Human Pancreatic Cancer Cells. Kuhara K, Tokuda K, Kitagawa T, Baron B, Tokunaga M, Harada K, Terasaki M, Uehara O, Ohta T, Takai R, Hamada JI, Kobayashi M, Shimo T, Nagayasu H, Kuramitsu Y. (PubMed) 
  • Active hexose-correlated compound down-regulates HSP27 of pancreatic cancer cells, and helps the cytotoxic effect of gemcitabine. Suenaga S, Kuramitsu Y, Kaino S, Maehara S, Maehara Y, Sakaida I, Nakamura K. (PubMed) 
  • Ovarian Microbiota, Ovarian Cancer and the Underestimated Role of HPV. Cazzaniga M, Cardinali M, Di Pierro F, Bertuccioli A. (PubMed) 
  • Active hexose-correlated compound and Bifidobacterium longum BB536 exert symbiotic effects in experimental colitis. Ocón B, Anzola A, Ortega-González M, Zarzuelo A, Suárez MD, Sánchez de Medina F, Martínez-Augustin O. (PubMed) 
  • Active Hexose-correlated Compound Down-regulates Heat Shock Factor 1, a Transcription Factor for HSP27, in Gemcitabine-resistant Human Pancreatic Cancer Cells. Tokunaga M, Baron B, Kitagawa T, Tokuda K, Kuramitsu Y. (PubMed) 
  • Low-energy amplitude-modulated radiofrequency electromagnetic fields as a systemic treatment for cancer: Review and proposed mechanisms of action. Tuszynski JA, Costa F. (PubMed) 
  • Efficacy of Lentinula edodes Mycelia Extract on Chemotherapy-Related Tasted Disorders in Pancreatic Cancer Patients. Yanagimoto H, Hirooka S, Yamamoto T, Yamaki S, Sekimoto M. (PubMed) 
  • The use of mushroom glucans and proteoglycans in cancer treatment. Kidd PM. (PubMed) 
  • Effect of active hexose-correlated compound in women receiving adjuvant chemotherapy for breast cancer: a retrospective study. Hangai S, Iwase S, Kawaguchi T, Kogure Y, Miyaji T, Matsunaga T, Nagumo Y, Yamaguchi T. (PubMed) 
  • Improved prognosis of postoperative hepatocellular carcinoma patients when treated with functional foods: a prospective cohort study. Matsui Y, Uhara J, Satoi S, Kaibori M, Yamada H, Kitade H, Imamura A, Takai S, Kawaguchi Y, Kwon AH, Kamiyama Y. (PubMed) 
  • Evaluation of active hexose correlated compound hepatic metabolism and potential for drug interactions with chemotherapy agents. Mach CM, Fugii H, Wakame K, Smith J. (PubMed) 
  • Effects of active hexose correlated compound on frequency of CD4+ and CD8+ T cells producing interferon-γ and/or tumor necrosis factor-α in healthy adults. Yin Z, Fujii H, Walshe T. (PubMed) 
  • Bioactive Immunomodulatory Compounds: A Novel Combinatorial Strategy for Integrated Medicine in Oncology? BAIC Exposure in Cancer Cells. Corradetti B, Vaiasicca S, Mantovani M, Virgili E, Bonucci M, Hammarberg Ferri I. (PubMed) 

Randomized, allopurinol-controlled trial of the effects of dietary nucleotides and active hexose correlated compound in the treatment of canine leishmaniosis. Segarra S, Miró G, Montoya A, Pardo-Marín L, Boqué N, Ferrer L, Cerón J. (PubMed) 

Dramatic prostate-specific antigen response with activated hemicellulose compound in metastatic castration-resistant prostate cancer. Turner J, Chaudhary U. (PubMed) 

Susan's Story

Dear all, I wanted to share a hopeful update from my health journey. About a year ago, a routine smear test showed that I was positive for high-risk HPV, although no abnormal cells were found. Because I had CIN1 around fifteen years ago, I worried the virus might have been persistent. I also underwent a colposcopy due to abnormal bleeding, but thankfully nothing concerning was discovered. Recently, I had another smear test and I’m very happy to say it came back HPV negative. I’ve always tried to maintain a healthy lifestyle, but about seven months before this latest test, I decided to be more proactive after learning about NovaHerbs AHCC. Around the same time, I also chose to get the HPV vaccine and have since received my first dose. I can’t say with certainty what made the difference, but after so many years, this result has left me both surprised and incredibly hopeful. I wanted to share my experience in case it offers reassurance or encouragement to anyone else going through something similar. Thank you all for your continued support. Warm regards.

 
 

Anna's Story

In March 2023, my HPV journey began with an unexpected call from my gynecologist’s office. Following a colposcopy in May, a biopsy revealed CIN 1/2 and CIN 2/3, a diagnosis that understandably filled me with fear and uncertainty. In my search for answers and alternatives, I came across a YouTube testimonial discussing AHCC. It was the first time I felt a sense of hope. I ordered NovaHerbs AHCC soon after and, beginning in April, started taking four 700 mg capsules every morning on an empty stomach, along with folic acid. While my diet wasn’t perfect, I made a conscious effort to support my body by eating leafy greens, cruciferous vegetables, and chia seeds daily. Wanting reassurance, I sought a second opinion. In July, an oncologist reviewed my case and diagnosed CIN 1, which differed from the initial findings. Then, during a second colposcopy in September, my gynecologist initially suspected CIN 2. However, after further evaluation, I was told there was no evidence of CIN or HPV. As I now await my next smear test, I remain cautiously optimistic. I’m not a medical professional, and I know every journey is different, but I truly believe AHCC played a meaningful role in my recovery. I’m sharing my experience in the hope that it offers comfort, strength, and direction to others facing similar challenges.

 
 

Kathy's Story

I want to share my HPV journey in the hope that it offers encouragement to others facing similar challenges. In July 2022, I received the unsettling news that I had high-risk HPV along with CIN 1. A colposcopy in August confirmed the diagnosis, and I remember feeling overwhelmed and anxious about what lay ahead. Rather than letting fear take over, I decided to take a proactive approach. During my research, I discovered NovaHerbs AHCC, a supplement that showed promising potential. I began incorporating it into my daily routine, taking 4 capsules (700 mg each) every morning on an empty stomach. Alongside this, I focused on supporting my overall well-being through better nutrition, regular movement, and mindfulness. Two weeks ago, I underwent a private colposcopy and anxiously awaited the results. To my immense relief, the outcome was HPV negative. This felt like a huge victory, not only over HPV but also over the anxiety that had accompanied the diagnosis. I’m sharing my experience not as a medical claim or endorsement, but to highlight what was meaningful in my own journey. For me, NovaHerbs AHCC felt like an important part of a broader, supportive approach to healing. To anyone currently battling HPV: please don’t lose hope. Stay proactive, take care of your body and mind, and remember that progress is possible. I hope my story offers reassurance, strength, and encouragement as you move forward on your own path. Wishing everyone clarity, resilience, and the best of luck on this journey.

 
 

John's Story

My struggle with HPV warts began in early 2019 and quickly took a toll not just on my health, but on my confidence, self-esteem, and relationships. After trying countless treatments with no success, I decided to give NovaHerbs AHCC a chance and made it part of my daily routine, without expecting an instant fix. Progress was gradual and required patience, but over time the warts became smaller, appeared less often, and eventually disappeared completely. Staying consistent changed everything, and today I’m free from HPV warts and finally able to live with confidence again, without the constant worry that once dominated my life.

 
 

Angela's Story

I hope this doesn’t feel like oversharing, but I want to help anyone who might be going through something similar. For three years, I lived with high-risk HPV, and every doctor’s visit came with hope followed by disappointment when the results were positive again. It was emotionally exhausting and made me feel like I was running out of options. I was first diagnosed in 2018, and although my Pap smears were normal for years, this past May I was told I had CIN 2/3, which pushed me to start researching on my own. That’s when I came across this product and decided to try it, taking it on an empty stomach for 6 months without any side effects, along with beta glucan and green tea extract. Recently, my OBGYN called to tell me my biopsy came back negative with no CIN, and while I know this won’t be everyone’s experience, for someone who has lived under the constant mental weight of high-risk HPV, that result meant everything. With so few options available, I felt it was worth sharing what has been helping me in the hope that it brings reassurance and encouragement to someone else.

 
 

Fatimah's Story

Let me share my experience in the hope that it helps someone else. I’ve always been diligent about getting my Pap smear every year and my results were always normal, so testing positive for HPV last year completely caught me off guard and honestly felt overwhelming, especially since I didn’t have insurance and was worried about the cost of more tests. While trying to figure out what to do next, I spoke with my cousin, who had also dealt with HPV and told me she had used NovaHerbs AHCC, which encouraged me to look into it myself. I decided to give it a try and took 5 capsules every morning for about six months. In April 2021, I went in for another Pap smear, and when weeks passed without a call, I assumed I had missed it, but when I finally contacted my doctor, she calmly told me that if anything had been wrong, they would have reached out. That’s when it really sank in that everything was clear and HPV was no longer detected. I’m sharing this not as medical advice, but because this is what worked for me, and I plan to continue using these supplements for the overall support they give me beyond this experience.

 
 

Savannah's Story

At 51, divorced with two adult children, finding out I had HPV hit me harder than I ever expected, bringing feelings of shame, confusion, and the sense that life had handed me yet another difficult challenge. I knew, though, that I didn’t want HPV to define me, and that’s when I learned about NovaHerbs, which felt like a small but meaningful ray of hope during a very dark time. Taking it every day became part of my routine, as normal as brushing my teeth or making my morning coffee, and while the journey had its ups and downs, I held on to cautious hope. Then came the moment I never thought I’d experience: I was told I no longer had HPV. It felt like a weight lifting from my shoulders and a light breaking through after months of uncertainty. The process wasn’t easy, but AHCC felt like quiet support in the background, helping me stay grounded and resilient. If you’re feeling lost or overwhelmed right now, please know that hope still exists. This journey helped me find my way back to myself, stronger, calmer, and more determined than ever.

 
 

Kalisha's Story

I went in for what I thought was just another routine check up and never expected to hear that I had HPV, especially after years of normal results, and being told there was no real cure made everything feel heavy and out of my control. I went home, overthought everything, and spent hours searching on Google, trying to understand what this diagnosis really meant and what, if anything, I could do about it. That’s how I came across NovaHerbs, and while I was skeptical and not expecting miracles, I decided to try it simply so I could feel like I was taking some kind of action. I took it consistently for months, even on days when I felt discouraged, and when it was finally time for my next smear, I tried not to get my hopes up. Hearing that HPV was no longer detected honestly left me in shock and brought an overwhelming sense of relief, like I could finally breathe again. I know everyone’s journey is different, but this is what helped me, and if you’re in that stressful waiting phase right now, feeling scared or alone, I just want you to know that sometimes things really do turn around.

 
 

Natalie's Story

Since my very first Pap smear at 21, abnormal results became something I almost expected. After a colposcopy showed level 2 changes, I underwent a LEEP procedure and was told to come back in six months. That follow-up brought mixed emotions. My cytology looked normal, but HPV was still there. At the time, I accepted what I was told, that HPV often clears on its own, and I didn’t question it much. Looking back, I wish I had taken the time to understand more instead of just waiting. Now at 26, without children, the idea of facing more aggressive options, including conversations around hysterectomy, was frightening. I felt like I needed to take ownership of my situation. After reading and learning more on my own, I chose to add AHCC into my life and stayed consistent with it over several months. When I went in for another colposcopy, I finally heard the words I had been hoping for: both my cytology and HPV results were normal. The supplements aren’t cheap, but for me, the peace of mind and the outcome made them worth it, and I’ve continued at a lower amount since. I know this won’t be everyone’s experience, but I truly wish I had been more proactive earlier, and I hope this helps someone else feel less powerless in their own journey.

 
 

David's Story

For years, dealing with HPV warts felt like a never-ending fight. I followed everything my doctor suggested creams, treatments, procedures but nothing ever seemed to last, and it was exhausting both physically and mentally. At one of my routine appointments, my doctor mentioned AHCC and said it had shown some promising results for people with HPV issues. I was skeptical, but at that point I was also tired of feeling stuck. I ended up choosing NovaHerbs AHCC and stuck with it for several months, even when I didn’t see much happening at first and started doubting it would help. Then slowly, over time, the warts began to shrink and show up less and less, until one day I realized they were gone. After so many years of frustration, that moment felt unreal and incredibly relieving. I’m finally wart free, and more than anything, I have my confidence back. I know everyone’s journey is different, but for me this made a real difference, and I wanted to share it in case someone else out there needs a bit of hope that things really can change.

 
 

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